Over the past four decades, significant progress has been made in the fight against HIV/AIDS, from groundbreaking scientific discoveries and advancements in treatment to expanded access to prevention and care services. Milestones such as the development of antiretroviral therapy, the global scale-up of HIV testing and treatment, and the reduction in mother-to-child transmission rates demonstrate the collective efforts and resilience of individuals, communities, and organizations working together to end the epidemic. As we celebrate these achievements, let us renew our commitment to building on this progress and achieving our ultimate goal of an AIDS-free generation.