Research and development are critical components of the HIV/AIDS response, driving advancements in treatment, prevention, and care. Investing in innovative approaches, such as long-acting antiretrovirals, novel vaccine candidates, and gene editing technologies, holds the potential to revolutionize the HIV/AIDS landscape and bring us closer to ending the epidemic. By supporting research initiatives, fostering collaboration between scientists and affected communities, and accelerating the translation of research findings into real-world impact, we can achieve breakthroughs that transform the trajectory of the HIV/AIDS epidemic for generations to come.