The social determinants of health, including poverty, discrimination, and lack of access to education and healthcare, play a significant role in driving the HIV/AIDS epidemic. Addressing these underlying factors is essential for achieving meaningful progress in ending the epidemic and promoting health equity for all. By implementing policies and interventions that address structural barriers to health, such as economic inequality, racism, and gender discrimination, we can create conditions that support health and well-being and reduce the disproportionate impact of HIV/AIDS on marginalized communities.