Legal and policy barriers, including criminalization of HIV transmission, punitive laws targeting key populations, and restrictions on harm reduction services, hinder efforts to prevent and treat HIV/AIDS. Advocating for policy reform is essential for addressing these barriers and creating enabling environments that support HIV/AIDS prevention, testing, treatment, and care. By engaging policymakers, raising awareness of the impacts of harmful laws and policies, and advocating for evidence-based approaches, we can promote legal and policy environments that protect human rights, promote public health, and end the stigma and discrimination associated with HIV/AIDS.